Momo Ayase (綾瀬 桃, Ayase Momo) is a high school girl who believes in ghosts and the supernatural. This is in part due to the influence of her grandmother, Seiko, working with them, but after she got teased for it at school, Momo cursed Seiko out for this, causing their relationship to become strained. After being abducted by Serpo aliens, she discovers she has psychokinetic powers, allowing her to visualize the "auras" of people and objects, and visualizes her power as giant hands to "grab" and control these auras. Momo has a celebrity crush on actor Ken Takakura, often becoming flustered whenever someone says his full name out loud. Although she and Okarun initially do not get along and constantly argue and fight with each other, after defeating Turbo Granny, they become close friends and throughout the course of the story, she develops strong feelings for Okarun. She decides to help him get his testicles back, with the ultimate goal of mending her relationship with her grandmother.

Ken Takakura (高倉 健, Takakura Ken) is a shy and friendless high school boy who tries to connect with Momo over their shared interests in the supernatural. Momo and her friends call him "Okarun" (オカルン)—derived from "occult" after his interest in the topic—so that she is not inadvertently reminded of her celebrity crush, though Okarun is oblivious to the origin of this. After being possessed by the Turbo Granny, Okarun gains the ability to enter a powerful demonic state, granting him immense speed but also a suave yet lethargic alternate personality. Okarun has been bullied frequently by his other classmates for his nerdy demeanor, but grows to take solace in his new friends and eventually becomes somewhat popular. Most of all, he values and cares a lot about his friendship with Momo due to her being his first real friend, and after his initial encounter with Taro and Hana, he realizes he is in love with Momo, eventually confessing to her. The loss and recovery of his testicles (kintama) is the main focal point for most of the series.

Aira Shiratori (白鳥 愛羅, Shiratori Aira) is the school idol of Kami High. Although she puts on the appearance of a ditzy and amiable person, she is actually incredibly vain and boasts a Messiah complex, a direct result of her inability to reconcile with the death of her mother at a young age. After obtaining one of Okarun's kintama, Aira reawakened her suppressed ability to see the supernatural, which coupled with her egomania, led her to believe that she was divinely chosen to exorcise yōkai and thus targets Momo, delusionally believing her and Okarun to be malevolent demons. The resulting confrontation culminated in her absorbing Acrobatic Silky's powers, giving her a similar transformation to Okarun as well as immense agility and prehensile hair. Aira subsequently allies with Momo and Okarun despite still thinking they are demons, and develops a crush for Okarun for his selfless nature. As the Family grows, she declares herself their leader, but becomes more selfless over time in making them her new friend group, and becomes friends with Momo even though they still argue occasionally.

Jin Enjoji (円城寺 仁, Enjōji Jin) is Momo's childhood friend and first crush, until he teased her over Seiko's rituals for her. He goes by the nickname "Jiji" (ジジ). After his parents were hospitalized as a result of his house being haunted and possessed by the Evil Eye, Enjoji moved in with Momo and Seiko before transferring over to Kami High and joining Momo's class. Though considered an attractive and athletic jock, Jiji is actually an eccentric dork who constantly throws praise onto others and views everyone in a positive light. After Jiji apologizes for his behavior, he and Momo rekindle their friendship, and as a result Okarun feels jealous over his relationship with Momo, which is later revealed to be somewhat valid as Jiji has developed a crush on her as well. He is possessed by the Evil Eye, who goes on a blind rampage when in control of Jiji's body.