Prison School (Japanese: 監獄学園プリズンスクール, Hepburn: Purizun Sukūru) is a Japanese manga series written and illustrated by Akira Hiramoto. It was serialized in Kodansha's Weekly Young Magazine from February 2011 to December 2017. Yen Press licensed the manga for English release in North America.

Set in Nerima Ward, the story takes place in a renowned and very strict private secondary school previously reserved for women. But the establishment changes its policy and educates five young men who, by their behavior, will very quickly find themselves in quarantine. They will have to face all kinds of pitfalls to get out of this critical situation and escape the clutches of the Student Union.

A 12-episode anime television series adaptation, produced by J.C. Staff and directed by Tsutomu Mizushima, aired from July to September 2015. A live-action drama television series aired from October to December 2015.

By March 2018, the manga had over 13 million copies in circulation. In 2013, Prison School won the 37th Kodansha Manga Award in the general category.

Hachimitsu Academy, one of the strictest girls' academies in Tokyo, was originally built in 1961 as a high-ranking sports academy and boarding school for elite young women. As the years went by, the chairman of the academy, surnamed Kurihara, has then decided to admit male students into their system. Kiyoshi Fujino is one of these new boys, but he discovers to his shock that he and his four friends—Takehito "Gakuto" Morokuzu, Shingo Wakamoto, Jouji "Joe" Nezu, and Reiji "Andre" Andou—are the only male students among 1,000 female pupils. The draconian laws that are still in place make the school even worse, which punishes even the most minor infractions with a stay in the school's prison.

In April 2011, the five young men all commit voyeurism in the school's bathing area with the lecherous philosophy of "all for one, one for all". Their capture and "arrest" by the Underground Student Council causes the five boys to receive an ultimatum: either stay a month in the school's Prison Block or be expelled. The boys are incarcerated in the Prison Block together and Kiyoshi is overwhelmed by the discovery that all the other boys are masochists that revel in the punishments handed to them by their attractive but vicious supervisors.