The 100 Girlfriends Who Really, Really, Really, Really, Really Love You (Japanese: 君のことが大大大大大好きな100人の彼女, Hepburn: Kimi no koto ga Dai Dai Dai Dai Daisuki na Hyaku-nin no Kanojo), often referred to simply as The 100 Girlfriends (100人の彼女, Hyaku-nin no Kanojo), or Hyakkano (100カノ), is a Japanese manga series written by Rikito Nakamura and illustrated by Yukiko Nozawa [ja]. It has been serialized in Shueisha's seinen manga magazine Weekly Young Jump since December 2019, with its chapters collected in 25 tankōbon volumes as of March 2026. The manga has been licensed for English release in North America by Seven Seas Entertainment.

The series follows high school student Rentaro Aijo, who, after 100 consecutive romantic rejections, is visited by the God of Love at a shrine. The god reveals a divine error has destined Rentaro with 100 soulmates, but warns that any soulmate he rejects will be cursed with fatal misfortune. To prevent their deaths, Rentaro resolves to simultaneously date them all at the same time.

An anime television series adaptation produced by Bibury Animation Studios aired from October to December 2023. A second season aired from January to March 2025. A third season is set to premiere in July 2026.

Rentaro Aijo has confessed to, and been rejected by, 100 girls in his lifetime. On the last day of middle school, he visits a shrine and prays that he get a girlfriend during his time at high school. Suddenly, the God of Love appears and tells Rentaro that the reason for his non-existent love life is because everyone is only supposed to have one soulmate in their life. Due to a clerical error on the God of Love's part, Rentaro is destined to have 100 which is to begin when he enters high school.

Sure enough, on the first day of high school, Rentaro meets the nymphomaniacal Hakari Hanazono and tsundere Karane Inda, the first two soulmates. They experience love at first sight, but Rentaro cannot decide between the two. That evening, he revisits the God of Love and is informed that if he does not return the feelings of any of his 100 soulmates, they will die in an accident. Not wanting such a fate to befall the girls, Rentaro decides to date all of them simultaneously, beginning with Hakari and Karane with their blessing.

As the story continues, more girls are introduced and become Rentaro's girlfriends, establishing a polyamorous relationship called the "Rentaro Family". The story revolves around Rentaro meeting new girlfriends and the interactions between the Rentaro Family members.