Seraph of the End (Japanese: 終わりのセラフ, Hepburn: Owari no Serafu), also known as Seraph of the End: Vampire Reign, is a Japanese manga series. It is written by Takaya Kagami, illustrated by Yamato Yamamoto and features storyboards by Daisuke Furuya. The series is set in a world that allegedly comes to an end at the hands of a "human-made" virus, ravaging the global populace and leaving only children under the age of thirteen untouched. It is at this time that vampires emerge from the recesses of the earth, followed by the emergence of other supernatural entities thought only to be myth. A young man named Yuichiro Hyakuya joins a vampire extermination unit to avenge the deaths of his family and reclaim his childhood best friend Mikaela Hyakuya from the vampires. It started publishing in Shueisha's Jump Square in September 2012.

An anime television series adaptation produced by Wit Studio was broadcast in two cours. The anime was split into two cours: the first aired from April to June 2015 and the second from October to December 2015. A series of light novels focused on Yu's superior, Guren Ichinose, have been written by Kagami and illustrated by Yamamoto. In North America, Viz Media licensed the series for an English language release, and it ran in Weekly Shonen Jump. The anime series was licensed by Funimation. It was later broadcast in the United Kingdom on Viceland in February 2018.

By October 2022, the Seraph of the End manga had over 15 million copies in circulation.

In 2012, the world allegedly comes to an end at the hands of a "man-made" virus, ravaging the global populace and leaving only children under the age of thirteen untouched. At the same time, the vampires emerge from the recesses of the earth, followed by age-old horrors of the dark thought to be only myth. They sweep the earth and claim it in a single violent stroke, subjugating the remnants of humanity and leading them beneath the surface to safety. This "protection" comes at the price of "donating" blood to their captors, not knowing that they are vampires.

At the age of twelve, Yuichiro and his friend and fellow orphan Mikaela plotted to escape along with the children in Hyakuya Orphanage. This plan was brought into action by Mikaela, who had been secretly donating his blood to the Seventh Progenitor, Ferid Bathory, in exchange for a map and a gun. However, this plan resulted in every last person besides Yuichiro dying at the hand of Ferid, and Mikaela sacrificing himself in order for Yuichiro to escape and be saved by members of the Moon Demon Company, an extermination unit of the Japanese Imperial Demon Army. Four years later, Yuichiro dedicates his life to destroy vampires and seek revenge against them for killing his "family." At the same time, it is revealed that Mikaela survived thanks to Third Progenitor and Vampire Queen Krul Tepes, who gave him some of her blood to turn him into a vampire. Mikaela does become a vampire soldier right under Ferid Bathory, and plans to find Yuichiro.